مشخصه‌یابی مولد 68Ge/68Ga و کنترل کیفی محصول شویش آن

نوع مقاله: مقاله پژوهشی

نویسندگان

پژوهشکده‌ی مواد و سوخت هسته‌ای، پژوهشگاه علوم و فنون هسته‌ای، سازمان انرژی اتمی ایران

چکیده

امروزه، 68Ga با توجه به ویژگی‌های واپاشی مناسب و امکان تهیه به طور مستقل از سیکلوترون و به شکل مولد 68Ge/68Ga با هزینه‌ای منطقی، یکی از گزینه‌های بسیار مناسب در مقطع‌نگاری نشری پوزیترون (PET) است. اخیراً مولد 68Ge/68Gaبر پایه‌ی قلع اکسید در کشور با موفقیت عرضه شده است. در این پژوهش، به منظور بررسی امکان استفاده از مولد ساخته شده در تولید و توسعه‌ی رادیوداروهای تشخیصی بر پایه‌ی Ga68 و به کارگیری آن در کاربردهای بالینی به صورت بهینه، مشخصات اصلی مولد شامل انتخاب محلول مناسب برای شستشو، منحنی شویش و بازده‌ی شستشوی تعیین شده و خلوص رادیونوکلیدی، خلوص شیمیایی و خلوص رادیوشیمیایی محصول شویش مولد ارزیابی شد. نتایج به دست آمده از این پژوهش نشان داد که مشخصات مولد توسعه داده شده در کشور قابل مقایسه با مولدهای 68Ge/68Ga  تولید شده در سایر کشورها، و دارای عملکرد مناسب برای استفاده در توسعه‌ی رادیوداروهای PET بر پایه‌ی 68Ga است.

کلیدواژه‌ها


عنوان مقاله [English]

Characterization of 68Ge/68Ga Generator and Quality Control of its Eluate

نویسندگان [English]

  • s Zolghadri
  • s Kakaei
  • H Yousefnia
  • A Bahrami-Samani
Materials and Nuclear Fuel Research School, Nuclear Science and Technology Research Institute, AEOI
چکیده [English]

Nowadays, due to thesuitable decay characteristics and possible production of 68Ga independent of the cyclotron in the form of 68Ge/68Ga generator with reasonable cost, this radionuclide is known as a suitable choice for PET imaging. Recently, SnO2 based 68Ge/68Ga generator was successfully prepared in Iran. In this study, in order to investigate the possible utilization of the made generator in the production and development of 68Ga-based diagnostic radiopharmaceuticals and optimal usage of the generator in the clinical applications, the main characteristics of the generator including the selection of appropriate eluent, elution profile and elution yield were determined, and radionuclidic, chemical and radiochemical purity of the eluate were evaluated. The results of this study indicated that the characteristics of the developed generator in Iran is comparable to those 68Ge/68Ga generators in other countries and it has suitable performance for the usage of developing 68Ga-based PET radiopharmaceuticals

کلیدواژه‌ها [English]

  • 68Ge/68Ga Generator
  • Elution Yield
  • Elution Profile
  • Radionuclidic Purity
  • Chemical Purity

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