تولید و کنترل کیفی سدیوم فلوئورید(F18Na) و پخش آن در بافت‌های موش صحرایی به عنوان رادیوداروی تصویربرداری استخوانی با PET

نوع مقاله: مقاله پژوهشی

نویسندگان

مرکز تحقیقات کشاورزی و پزشکی هسته‌ای، سازمان انرژی اتمی ایران، صندوق پستی:498-31485، کرج ـ ایران

چکیده

سدیوم فلوئورید (F18Na)، رادیوداروی توموگرافی گسیل پوزیترونی(PET) است که در تصویربرداری از استخوان کاربرد دارد. یونهای فلوئورید-18 در اثر بمباران آب غنی شده O218H با پروتونهای شتاب داده شده درسیکلوترون، تولید و به محلول قابل تزریق سدیوم فلوئورید، تبدیل شدند.کنترل کیفی محلول سدیوم فلوئورید با بررسی خلوص رادیونوکلئیدی، خلوص رادیوشیمیایی، خلوص شیمیایی و تستهای میکروبی به انجام رسید. پس از کنترل کیفی، محلول سدیوم فلوئورید به موش صحرایی تزریق گردید و چگونگی پخش یونهای فلوئورید-18 در بافتهای موش صحرایی با تصویربرداری به وسیله سیستم تصویربرداری همزمانی بررسی شد. در این مقاله فرایند و پارامترهای تولید و روشهای کنترل کیفی محصول نهایی بررسی شده است. همچنین تصاویر همزمانی از بافتهای موش صحرایی و چگونگی پخش یونهای فلوئورید-18 در بافتهای آن بررسی شده است. تصاویر، بیشترین تجمع یونهای فلوئورید-18 را در بافتهای استخوانی نشان می‌دهند.

کلیدواژه‌ها


عنوان مقاله [English]

Production and Quality Control of Sodium Fluoride (Na18F) and It's Distribution in Rate’s Lesions as PET Radiopharmaceutical for Bone Scan

نویسندگان [English]

  • M AKhlaghi
  • M Mirzaii
  • A.R Jalilian
  • N Shadanpoor
  • S Moradkhani
  • F Saddadi
  • M Mostaan
  • G.R Aslani
  • M.R Ensaf
چکیده [English]

Sodium fluoride (Na18F) is the positron emission tomography (PET) radiopharmaceutical for skeletal imaging. The fluoride-18 ions are produced in NRCAM cyclotron IBA, Cyclone-30 by bombardment of enriched water (H218O) with accelerated protons. The produced fluoride-18 ions are converted to injectable sodium fluoride solution. Then, the quality control of sodium fluoride solution is carried out with identification of the radionuclide, radiochemical and chemical purity, pyrogenicity and sterility. After the quality control, the sodium fluoride solution is injected into the rate’s lesion and  the distribution of fluoride-18 ions is investigated with imaging by the use of a dual-headed coincidence system. In this paper the process and parameters of the production, methods of the quality the control, and the coincidence images of the rat's lesions and the distribution of fluoride-18 ions are described. The obtained images show that the maximum uptake of the fluoride-18 ions is in the bone lesions.

کلیدواژه‌ها [English]

  • Sodium Fluoride (Na18F)
  • Fluoride 18
  • Bone Tissues
  • Radiopharmaceuticals
  • Skeletal Imaging
  • Positron Emission Tomography
  • Enriched Water
  • Quality Control
  • Uptake
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