عنوان مقاله [English]
نویسندگان [English]چکیده [English]
Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) is the most important copper radiopharmaceutical used in clinical experiments. In this work, Copper-61 (T1/2=3.33 h) production process was accomplished via the nat.Zn(p,xn)61Cu, using 22MeV protons, and the current of 150 μA, resulted in 6.33 Ci of copper-61 with the production yield of 33.3 mCi/μAh. The complexing agent, PTSM, was synthesized and its structure was confirmed by the common spectroscopic methods, followed by radiolabeling with 61Cu-CuCl2. The final radiopharmaceutical solution underwent common quality control tests for animal injection.