تهیه رادیوداروی [Cu61] ـ پیـروآلدئید بیـس (4 Nـ متیـل تیوسمی کاربازون) - PTSM) [Cu61] (و کنترل کیفی آن برای تشخیص پزشکی به روش PET

نوع مقاله: مقاله پژوهشی

نویسندگان

مرکز تحقیقات کشاورزی و پزشکی هسته‌ای، سازمان انرژی اتمی ایران، صندوق پستی: 498- 31485، کرج- ایران

چکیده

یکی از مهمترین رادیوداروهای حاوی رادیوایزوتوپهای مس که در حال حاضر به صورت آزمایشی به مصارف بالینی می‌رسد، رادیوداروی «پیروآلدئید بیس ـ(4Nـ متیل تیوسمی کاربازون)»(Cu-PTSM) است. در این کار پژوهشی مراحل تولید رادیوایزوتوپ مس-61 به صورت محصول بمباران روی طبیعی در اثر واکنش هسته‌ای Cu61natZn(p,xn) به وسیلة پروتونهای شتاب گرفته در سیکلوترون با انرژی 22 مگا الکترون ولت و شدت جریان 150 میکرو آمپر، که منجر به تولید مس-61 با آکتیویته 6.33  کوری و بهره تولید حدود 33.3  میلی کوری بر میکروآمپر- ساعت گردید توصیف شده، سپس سنتز و تأیید کامل ساختار مولکولی مادّه چنگکی پیروآلدئید بیس ـ(4ـ Nـ متیل تیوسمی کاربازون) به روشهای طیف سنجی، و در نهایت نشاندارسازی آن با مس-61 به صورت کلرید گزارش شده است. در این بررسی، کنترل کیفی کامل رادیودارو به منظور اطمینان از قابلیت تزریق آن به موجود زنده نیز انجام شد.

کلیدواژه‌ها


عنوان مقاله [English]

Preparation and Quality Control of [61Cu]Pyruvaldehyde-Bis (N4-Methylthiosemicarbazone) Complex for PET Diagnosis

نویسندگان [English]

  • A.R Jalilian
  • P Rowshanfarzad
  • M Sabet
  • M Kamalidehghan
  • M Mirzaii
  • A.A Rajamand
چکیده [English]

Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM)‍ is the most important copper radiopharmaceutical used in clinical experiments. In this work, Copper-61 (T1/2=3.33 h) production process was accomplished via the nat.Zn(p,xn)61Cu, using 22MeV protons, and the current of 150 μA, resulted in 6.33 Ci of copper-61 with the production yield of 33.3 mCi/μAh. The complexing agent, PTSM, was synthesized and its structure was confirmed by the common spectroscopic methods, followed by radiolabeling with 61Cu-CuCl2. The final radiopharmaceutical solution underwent common quality control tests for animal injection. 

کلیدواژه‌ها [English]

  • Copper-61
  • Radiopharmaceuticals
  • nuclear reactions
  • copper compounds
  • Quality Control
  • 61Cu-PTSM
  • PET
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